Nonclinical and Clinical ServicesWe have renewed our web page for Nonclinical Services. Please find the link here

Nonclinical Studies

The Toxicological Science Division serves to perform nonclinical studies by taking full advantages of a vast array of techniques and renowned reliability that the former Mitsubishi Chemical Safety Institute Ltd. (MSI) had acquired through its broad range of accumulated experience.

Tests on Chemical Substances

Ecotoxicity Studies

We have been conducting ecotoxicity studies since establishing our business in 1977. Our vastly-experienced staff conducts tests/studies at the highest level of reliability, promptness, safety, and analysis technique. All of our services are offered at very competitive rates.

Ecotoxicity Studies Required for Registration of Agrochemicals and Chemical Substances

We conduct tests on the effects of agrochemicals (raw materials and products) on aquatic plants and animals (compliant with the Agricultural Chemicals Regulation Law) as well as effects of general chemical substances on living organisms in the environment (compliant with the Chemical Substances Control Law). Moreover, we conduct ecotoxicity studies in compliance with the US TSCA/FIFRA and OECD guidelines as well as GLP standards. Along with internationally recommended studies of aquatic life including algae, water fleas, and fish, we also conduct studies of other species including freshwater shrimp.

  • Growth Inhibition Tests in Algae (72 hours)
  • Acute Immobilization Tests in Water Fleas (48 hours)
  • Reproduction Tests in Water Fleas (21 days)
  • Acute Toxicity Tests in Fish (96 hours)
  • Early Life Stage Toxicity (ELST) Tests in Fish (about 40 days)
  • Respiration Inhibition Tests in Activated Sludge (several hours)

Ecotoxicity Studies Compliant with Various Regulations/Requirements

Nowadays, various regulations on chemical substances including final products are being enforced and revised worldwide. Including regulations which are expected to come into force in the very near future, REACH, RoHS, ELV, GHS, China’s environmental regulations, MARPOL, and many others are already being enforced around the world. The key phrase for all of the above regulations is “Protection of human health and the environment”. We conduct a variety of studies/tests to meet the needs of clients. Please do not hesitate to contact us to discuss your specific needs.

  • Studies of Bulk Liquid Substances

    To prevent marine pollution from ships, noxious bulk liquid substances should be assigned to an appropriate pollution category on the basis of their GESAMP hazard profile. Transport of these substances is also regulated by MARPOL Annex II and IBC code (International Bulk Chemical Code), which are enforced by the International Maritime Organization (IMO).

  • Services for self waste management of industrial sewages

    We conduct toxicity assessments to test the influence of industrial wastewater to the environment and also conduct aquatic toxicity or bioaccumulation studies to test the influence of veterinary drugs to the aquatic environment.
    In Japan, for the assessment of industrial wastewater, a new environmental impact assessment and management methods which use bioassay are going to be introduced to the market. We conduct WET study using argae, ceriodaphnia dubia and zebrafish in compliance with guidelines. We support clients from the design of industrial wastewater sampling plan, implementation of bioassay, to the evaluative analysis of the test results to meet our clientsf needs.

  • Studies Compliant with GHS and MSDS Requirements

    There are a wide range of hazardous property classification based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS). We can provide data to facilitate submission of material safety data sheet (SDS or MSDS) by evaluating effects on human health and the environment including biodegradation, bioaccumulation, and ecotoxicity.

  • Studies of Risk Management Including Eluted Substances and Drainage

    We perform studies concerning effects of eluted substances in the developmental stage on various products and materials, including electrical and electronic equipment and drainage on plants and animals in the environment, as well as the effects of animal drugs in aquatic life and their bioaccumulation. Various bioassays are available to prevent environmental risks and ranking at the screening stage.

  • Studies of Microbial Pesticides and Microorganisms for Bioremediation

    We conduct studies of microbial pesticides including 21-day reproduction tests in water fleas and 30-day prolonged toxicity tests in fish. We also conduct environmental safety studies of microorganisms for industrial use such as bioremediation, including 72-hours growth inhibition studies in algae. The microbial biomass in test solutions will be determined in the above studies.

Others

Currently, we are involved in development of new techniques including detection of mutagenic substances in transgenic fish, in vitro toxicity evaluation in fish cells, evaluation in embryonic and larval fish and daphnia embryos, and evaluation of endocrine-disrupting substances.

All of our research and studies are in strict adherence to the laws concerning protection and management of animals with full respect of the standards concerning care and management of test animals, and have been accepted and certified for animal welfare practices.



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