Since the introduction of GLP quality standards into our testing facilities, LSI Medience has been conducting in vivo and in vitro toxicity tests, genotoxicity tests, safety pharmacology tests, pharmacological tests, TK/PK analysis, and pharmacokinetic tests as a GLP-compliant contract research organization. Based on our experience and expertise, we have been providing educations on various experimental techniques at the clients’ request.
Our researchers with their years of experience, expertise, and specialized certifications are able to offer services suitable to our clients’ request. It is also possible for us to provide services other than those below, please contact us for details.
LSI Medience offers pathology training programs to our clients and, through our wealth of experience and knowledge of toxicologic pathology assessment, we help improve the technical skills of their toxicologic pathology staff. We offer various training and support services: training for new pathologists, training for long-term studies (age-related change or tumor, etc.), support for writing articles, and consulting services (pathological findings, etc.) including peer review. For more details about the above services and other inquiries, please do not hesitate to contact us.
1.1Histopathological training services (basic course)
1.2Specimen rental and lecturing services
1.3Support for writing articles and studies services
1.4Peer review and consulting services
LSI Medience provides various experimental technique training services on experimental operations in safety tests and pharmacological tests. Our experienced technicians (senior laboratory animal technicians, fundamental ophthalmologists, etc.) provide technical guidance in actual operation and measurement settings to help improve experimental skills. We will also provide on-site services upon request.
2.1Animal experiment techniques Administration, blood collection, necropsy, surgery, cerebrospinal fluid collection, ophthalmologic examination (light reflex, ophthalmoscopy, intraocular pressure measurement, corneal endothelium examination, corneal thickness examination, and electroretinogram examination), and various other examinations
2.2Genotoxicity tests Ames test, chromosome aberration test, in vitro micronucleus test, in vivo micronucleus test, operation related to comet assay etc.
2.3Reproductive developmental toxicity test Estrus cycle test, sperm examination, production of pregnant animals (mating), caesarean section examination, external examination, visceral examination, skeletal examination, intrapartum test, nursing test, developmental differentiation test, functional examination, motor coordination examination, learning ability examination, and emotionality examination
2.4In vivo test using RI labeled substance Blood concentration (administration, blood collection), distribution (QWBA, tissue extraction method), and excretion (urine, feces, bile)
LSI Medience supports in the preparation of various documents according to clients’ requests. Please consult about inspection of studies entrusted to external facilities.
3.1Provision of GLP education and instruction material preparation support
3.2Standard operating procedures preparation support
3.3Inspection of study entrusted to external facility
In response to "We would like to gradually proceed while considering experiments using minipigs but lack animal housing and knowledge of experimental technique." of our clients', we offer our rental laboratory service.
We provide animal housing facilities that are GLP compliant, and where it is possible to prepare animals and various examination equipment etc. and conduct measurements in compliance to various GLP/guidelines according to our clients’ needs. In addition, we are able to provide support services according to our clients’ needs such as our client conducts the administration and treatment while our researchers provide serial blood sampling. We are able to provide the flexibility that our clients need for successful research. Please feel free to contact us about the above services and other possible requests.
Animal management, clinical observation, blood collection, cardiovascular examination, ophthalmological examination, operation, blood examination, urinalysis, pathological examination
1 week to
1 month at the fastest
|Inquiry||Client||Inquiry to our sales staff.
Please submit the contents of experiment and the number of necessary animals.
|Estimate||LSI Medience||Presentation by our sales staff.|
|Reservation of pigs||LSI Medience||The limitations of cancellation of animals will vary depending on purchase age and production status.
If we have stock animals, we may propose those animals for use.
|Application||Client||Submit study application form.|
|Draft protocol||LSI Medience||The study number is assigned and communication between the client and LSIM begin.|
|Application for experiment||LSI Medience||Application to IACUC (depending on the experiment contents, we consult in advance the possibility of implementation and alternative plans at the inquiry stage.)|
|Finalization of protocol||LSI Medience||Initiation of study|
|Arrival of pigs||LSI Medience||For new purchases, 10 days of quarantine + a few days of acclimation.
When using our stock animals, clients can start experiment promptly.
|Experimental period||Client||Clients receive introduction education and SOP education to experiment at our facility. (about 3 hours)|
|The daily management of animals is left to our personnel.
Clients come to the facility and conduct their experiment. Our personnel will provide support when necessary.
|A waiting room (reception office) will be provided.|
We provide information for clients concerning development of pharmaceuticals, agrichemicals, and chemical substances etc.
Please note and understand that we cannot respond to requests from competitors or free e-mail addresses.
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