Nonclinical and Clinical ServicesWe have renewed our web page for Nonclinical Services. Please find the link here

Nonclinical Studies

The Toxicological Science Division serves to perform nonclinical studies by taking full advantages of a vast array of techniques and renowned reliability that the former Mitsubishi Chemical Safety Institute Ltd. (MSI) had acquired through its broad range of accumulated experience.

Tests on Pharmaceuticals and Agrochemicals

Toxicity Studies

  • Single Dose Toxicity Studies (Acute Toxicity Studies)
  • Repeated Dose Toxicity Studies
  • Carcinogenicity Studies
  • Inhalation Toxicity Studies
  • Reproductive and Developmental Toxicity Studies, Reproduction Toxicity Studies, Teratogenicity Studies
  • Local Irritation Studies
  • Sensitization Studies
  • Antigenicity Studies
  • Immunotoxicity Studies
  • Safety Evaluation of Microbial Pesticides
  • Others
  • For details

Genotoxicity Studies

  • in vitro Tests
    • Reverse Mutation Tests (Ames Tests)
    • Chromosomal Aberration Tests
    • in vitro Micronucleus Tests
    • MLA Tests
    • Metabolic Cooperation Inhibition Tests (IMC Tests)
  • in vivo Tests
    • Micronucleus Tests
    • RDS Tests
    • UDS Tests
  • Screening Tests (in vitro)
    • Ames Tests
    • in vitro Micronucleus Tests
    • Metabolic Cooperation Inhibition Tests (IMC Tests)
    • Chromosomal Aberration Tests
    • MLA Tests
  • Screening Tests (in vivo)
    • Micronucleus Tests
    • RDS Tests
    • UDS Tests
  • For details

Pharmacology Studies

  • Safety Pharmacology Studies of Pharmaceuticals
    • Safety Pharmacology Core Battery Studies
    • Follow-up Studies
    • Supplemental Safety Pharmacology Studies
  • Studies Concerning the Effects of Pesticides on Biological Function/ Efficacy Pharmacological Tests
    • Central Nervous System
    • Cardiovascular System
    • Digestive System
    • Urinary System
    • Respiratory System
    • Blood System
    • Inflammation, Immune, and Allergy System
    • Metabolic and Endocrine System
    • Skin
    • Cancer
    • Others
  • For details

Pharmacokinetic Studies

  • in vivo Tests
    • Absorption, Distribution, Metabolism, and Excretion (ADME Studies)
  • in vitro Tests
    • in vitro Metabolism Studies
    • Identification of CYP Isoforms Involved in Drug Metabolism
    • Drug Interaction
    • Inhibition of Drug Metabolizing Enzymes
    • Protein Binding Studies
    • Blood Distribution Studies
    • Transporter Studies
    • Percutaneous Absorption Studies
    • Membrane Permeability Studies with Caco-2 Cells
  • Separation, Determination, and Structure Elucidation of Metabolites
    • Separation, Determination, and Structure Elucidation of Biological Samples and Metabolites in in vitro Reaction Solutions (LC/MS/MS and NMR [500 MHZ] are available in the RI control area).
  • Measurement of Drug Metabolic Enzyme Activity (Ex Vivo)
    • Measurement of enzyme activities of liver samples collected in toxicity tests. Identification of enzymes induced.
  • For details

TK/PK Studies

  • Toxicokinetic Studies
  • Pharmacokinetic Studies
    • Blood Kinetic Tests
    • Bioavailability Tests
    • Bioloequivalence Tests
    • Drug Interaction Tests
    • Clinical Pharmacokinetic Studies
  • Development of Analytical Methods
    • Analysis Method Validation by LC/MS/MS etc.
  • Others
    • Pharmacokinetic Analysis
    • Statistical Analysis
  • For details

Concentration Analysis of Dosing Formulation and Characteristic and Stability Study of Test Substance

  • Concentration Analysis of the Test Substance in Dosing Formulations
  • Concentration Analysis of the Test Substance in Feed Preparation
  • Characteristic and Stability Studies
  • Development and Establishment of Analysis Methods
  • For details

Specification and Stability Tests

  • Specification Tests
  • Stability Tests
  • Stress Tests
  • Acceleration Test
  • For details

Immunoassay Related Studies and In Vitro Tests/Bioassay

  • Measurement of Hormones/Biomarkers
  • Antibody/Biochemical Tests
    • Purification, Modification, and Labeling of Antibodies
    • Production or development of Immunoassay System
    • Preparation of Reagents (PanaTESTR Series) for Animals
  • in vivo and ex vivo Testing
  • For details

Cell Function Research

All of our research and studies are in strict adherence to the laws concerning protection and management of animals with full respect of the standards concerning care and management of test animals, and have been accepted and certified for animal welfare practices.



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