Nonclinical and Clinical ServicesWe have renewed our web page for Nonclinical Services. Please find the link hereWe have renewed our web page for Chemical Substance Management. Please find the link here

Nonclinical Studies

The Toxicological Science Division serves to perform nonclinical studies by taking full advantages of a vast array of techniques and renowned reliability that the former Mitsubishi Chemical Safety Institute Ltd. (MSI) had acquired through its broad range of accumulated experience.

Tests on Pharmaceuticals and Agrochemicals

Genotoxicity Studies

We conduct various GLP tests and studies required for the notification of pharmaceuticals, cosmetics, agrochemicals, and industrial chemicals. With our abundant experience, we also conduct tests and studies in compliance with the GLP requirements of the USA and EU. Moreover, various screening tests as well as tests for the material safety data sheet (MSDS) are also available. We continue to emphasize the development of new techniques to accurately evaluate risks to humans. Please contact us for detailed information such as background data, achievements in the tests and studies below.

In vitro Tests

  • Reverse Mutation Tests (Ames Tests)
  • Chromosomal Aberration Tests
  • In Vitro Micronucleus Tests
  • Mouse Lymphoma Assays (MLA)
  • Cell Transformation Assays
  • In Vitro 3T3 NRU Phototoxicity Tests

In Vivo Tests

  • In Vivo Micronucleus Tests
  • Replicative DNA Synthesis (RDS) Tests
  • Unscheduled DNA Synthesis (UDS) Tests
  • Single Cell Gel Electrophoresis Assays (Comet Assays)
  • Combination of Micronucleus Assay and Comet Assay
We also have abundant experience in TK studies associated with in vivo tests.

Screening Studies

  • In Vitro Tests
  • In Vivo Tests
We can produce results from 1 week to 1 month with the appropriate test system.

All of our research and studies are in strict adherence to the laws concerning protection and management of animals with full respect of the standards concerning care and management of test animals, and have been accepted and certified for animal welfare practices.

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