Toxicity Studies

• Single Dose Toxicity Studies (Acute Toxicity Studies)
• Repeated Dose Toxicity Studies
• Carcinogenicity Studies
• Inhalation Toxicity Studies
• Reproductive and Developmental Toxicity Studies, Reproduction Toxicity Studies, Teratogenicity Studies
• Local Irritation Studies
• Sensitization Studies
• Antigenicity Studies
• Immunotoxicity Studies
• Safety Evaluation of Microbial Pesticides
• Others
• For details

Genotoxicity Studies

• in vitro Tests
  • Reverse Mutation Tests (Ames Tests)
  • Chromosomal Aberration Tests
  • in vitro Micronucleus Tests
  • MLA Tests
  • Metabolic Cooperation Inhibition Tests (IMC Tests)
• in vivo Tests
  • Micronucleus Tests
  • RDS Tests
  • UDS Tests
• Screening Tests (in vitro)
  • Ames Tests
  • in vitro Micronucleus Tests
  • Metabolic Cooperation Inhibition Tests (IMC Tests)
  • Chromosomal Aberration Tests
  • MLA Tests
• Screening Tests (in vivo)
  • Micronucleus Tests
  • RDS Tests
  • UDS Tests
• For details

Pharmacology Studies

• Safety Pharmacology Studies of Pharmaceuticals
  • Safety Pharmacology Core Battery Studies
  • Follow-up Studies
  • Supplemental Safety Pharmacology Studies
• Studies Concerning the Effects of Pesticides on Biological Function/ Efficacy Pharmacological Tests
  • Central Nervous System
  • Cardiovascular System
  • Digestive System
  • Urinary System
  • Respiratory System
  • Blood System
  • Inflammation, Immune, and Allergy System
  • Metabolic and Endocrine System
  • Skin
  • Cancer
  • Others
• For details

Pharmacokinetic Studies

• in vivo Tests
  • Absorption, Distribution, Metabolism, and Excretion (ADME Studies)
• in vitro Tests
  • in vitro Metabolism Studies
  • Identification of CYP Isoforms Involved in Drug Metabolism
  • Drug Interaction
  • Inhibition of Drug Metabolizing Enzymes
  • Protein Binding Studies
  • Blood Distribution Studies
  • Transporter Studies
  • Percutaneous Absorption Studies
  • Membrane Permeability Studies with Caco-2 Cells
• Separation, Determination, and Structure Elucidation of Metabolites
  • Separation, Determination, and Structure Elucidation of Biological Samples and Metabolites in in vitro Reaction Solutions (LC/MS/MS and NMR [500 MHZ] are available in the RI control area).
• Measurement of Drug Metabolic Enzyme Activity (Ex Vivo)
  • Measurement of enzyme activities of liver samples collected in toxicity tests. Identification of enzymes induced.
• For details

TK/PK Studies

• Toxicokinetic Studies
• Pharmacokinetic Studies
  • Blood Kinetic Tests
  • Bioavailability Tests
  • Bioloequivalence Tests
  • Drug Interaction Tests
  • Clinical Pharmacokinetic Studies
• Development of Analytical Methods
  • Analysis Method Validation by LC/MS/MS etc.
• Others
  • Pharmacokinetic Analysis
  • Statistical Analysis
• For details

Concentration Analysis of Dosing Formulation and Characteristic and Stability Study of Test Substance

• Concentration Analysis of the Test Substance in Dosing Formulations
• Concentration Analysis of the Test Substance in Feed Preparation
• Characteristic and Stability Studies
• Development and Establishment of Analysis Methods
• For details

Specification and Stability Tests

• Specification Tests
• Stability Tests
• Stress Tests
• Acceleration Test
• For details

Immunoassay Related Studies and In Vitro Tests/Bioassay

• Measurement of Hormones/Biomarkers
• Antibody/Biochemical Tests
  • Purification, Modification, and Labeling of Antibodies
  • Production or development of Immunoassay System
  • Preparation of Reagents (PanaTESTR Series) for Animals
• in vivo and ex vivo Testing
• For details